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By 2010, newer medications such as orlistat, bupropion/naltrexone, and phentermine/topiramate were approved for long-term use.(5) However, these agents generally failed to achieve a long-term placebo-adjusted mean weight loss exceeding 10% at tolerable doses and were frequently associated with acute or chronic side effects at higher doses.(6) Modern Developments: GLP-1 Receptor Agonists A significant milestone occurred in 2014 with FDA approval of liraglutide, the first glucagon-like peptide-1 receptor agonist (GLP-1 RA) for chronic weight management.(6) Clinical trials demonstrated that liraglutide produced 4.5%6% average body weight reduction after one year of treatment